ProteinScanner: Integrated Tools for Structural Bioinformatics
ProteinScanner is a computational platform developed by the Aminpour Lab to support structural biology and drug discovery research. The platform currently includes three modules designed to analyze protein–protein interactions, protein–ligand binding, and mutation impact.
Each module is equipped with interactive visualization, AI-enhanced modeling, and predictive analytics tailored for molecular biology applications. Users may upload PDB files or use preset examples to explore tool features.
PPI-Scanner: Protein–Protein Interaction
Analyze potential interaction interfaces between two protein chains using structure-based modeling and AI. Submit two PDBs (e.g., Spike protein and an antibody) to explore predicted binding regions and interaction metrics.
PLI-Scanner: Protein–Ligand Interaction
Identify ligand binding pockets and simulate docking scenarios. This module predicts active site residues, ligand poses, and interaction affinities using molecular descriptors and optional ML-driven scoring.
MUT-Scanner: Mutation Analysis
Investigate how specific amino acid mutations influence protein stability and structure. Use visualization tools to highlight residues, analyze solvent exposure, and assess potential impact using evolutionary and structural context.